M. M. Gaglia

N-terminal acetylation controls multiple functional aspects of the influenza A virus ribonuclease PA-X

This paper investigates how N-terminal acetylation of the influenza A virus protein PA-X affects its nuclear localization and host shutoff activity, revealing that acetylation of the initiator methionine is specifically required for host shutoff.

Caspase-mediated regulation and cellular heterogeneity of the cGAS/STING pathway in Kaposi's sarcoma-associated herpesvirus infection

This study shows that caspase activity inhibits cGAS during KSHV infection to suppress type I IFN production, revealing a novel immune evasion mechanism and highlighting caspases as potential therapeutic targets.

The cut site specificity of the influenza A virus endoribonuclease PA-X allows it to discriminate between host and viral mRNAs

The paper identifies GCUG tetramers in hairpin loops as PA-X cleavage sites, showing PA-X discriminates host from viral mRNAs by targeting GCUG-rich regions prevalent in host transcripts.

The influenza A virus host shutoff factor PA-X is rapidly turned over in a strain-specific manner

This study shows that the influenza A virus PA-X protein is rapidly turned over, with strain-specific half-lives influenced by sequences in its C-terminal domain, and longer half-life correlates with higher host shutoff activity.

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

This paper shows that defective influenza A virus RNAs trigger MAVS-dependent upregulation of HLA class I proteins, which may aid viral evasion of innate immunity.