Author

I. J. MacRae

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Joo· 2 shared T. A. Anzelon· 2 shared A. Arif· 1 shared C. Andersson· 1 shared C. Bastiaanssen· 1 shared D. C. Swarts· 1 shared D. M. Ozata· 1 shared D. Tamarit· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

C. Joo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RNA-guided RNA silencing by an Asgard archaeal Argonaute

C. Bastiaanssen, P. B. Ugarte, K. Kim, Y. Feng, G. Finocchio, T. A. Anzelon, S. Kostlbacher, D. Tamarit, T. J. G. Ettema, M. Jinek, I. J. MacRae, C. Joo, D. C. Swarts, F. Wu

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

bioRxiv · Dec 14, 2023Microbiology

The conserved zinc-finger protein GTSF1helps PIWI proteins achieve their full catalytic potential

A. Arif, S. Bailey, N. Izumi, T. A. Anzelon, D. M. Ozata, C. Andersson, I. Gainetdinov, I. J. MacRae, Y. Tomari, P. D. Zamore

This study identifies GTSF1 as an auxiliary protein that enhances the catalytic activity of PIWI proteins by potentiating their weak piRNA-directed RNA cleavage.

bioRxiv · May 4, 2021 · PreprintBiochemistry

Skipping and sliding to optimize target search on protein-bound DNA and RNA

M. Klein, T. J. Cui, I. J. MacRae, C. Joo, M. Depken

The paper shows that skipping and sliding motions allow searchers to maintain search speed on crowded nucleic-acid substrates, as demonstrated by analyzing human and bacterial Argonaute proteins.

bioRxiv · Jun 4, 2020 · PreprintBiophysics

Beyond the seed: structural basis for supplementary mircoRNA targeting

J. Sheu-Gruttadauria, Y. Xiao, L. F. R. Gebert, I. J. MacRae

The paper reports the structure of Ago2 bound to a target RNA using both seed and supplementary regions, showing supplementary interactions significantly enhance target affinity.

bioRxiv · Nov 22, 2018Biochemistry