Author

I. K. Gaszek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Approach:simulation· 1

Frequent Co-Authors

A. R. Atilgan· 2 shared C. ATILGAN· 2 shared E. Toprak· 2 shared H. Abdizadeh· 1 shared I. Kantarcioglu· 1 shared K. Reynolds· 1 shared M. S. Yildiz· 1 shared T. Batur· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

A. R. Atilgan

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2 papers

Recent·Most cited

Elucidating TolC Protein Dynamics: Structural Shifts Facilitate Efflux Mediated β-lactam Resistance

I. Kantarcioglu, I. K. Gaszek, T. F. Guclu, M. S. Yildiz, A. R. Atilgan, E. Toprak, C. ATILGAN

This study investigates TolC protein dynamics in Gram-negative bacteria, identifying structural shifts that facilitate β-lactam efflux and resistance, with implications for antibiotic design.

bioRxiv · Feb 22, 2024Biophysics

High-order epistasis in catalytic power of dihydrofolate reductase gives rise to a rugged fitness landscape in the presence of trimethoprim selection

Y. T. Tamer, I. K. Gaszek, H. Abdizadeh, T. Batur, K. Reynolds, A. R. Atilgan, C. Atilgan, E. Toprak

The paper quantifies high-order epistasis in DHFR mutations under trimethoprim selection, revealing complex fitness landscapes and implications for inhibitor design.

bioRxiv · Aug 22, 2018Evolutionary Biology