E. Toprak

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

Elucidating TolC Protein Dynamics: Structural Shifts Facilitate Efflux Mediated β-lactam Resistance

This study investigates TolC protein dynamics in Gram-negative bacteria, identifying structural shifts that facilitate β-lactam efflux and resistance, with implications for antibiotic design.

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

The paper shows that gut bacteria can survive antibiotic treatment without developing resistance by acquiring mutations that enhance their ability to persist and invade intestinal cells.

High-order epistasis in catalytic power of dihydrofolate reductase gives rise to a rugged fitness landscape in the presence of trimethoprim selection

The paper quantifies high-order epistasis in DHFR mutations under trimethoprim selection, revealing complex fitness landscapes and implications for inhibitor design.