Phenotypic profiling of macrocyclic lactones on parasitic Schistosoma flatworms
K. T. Ryan, N. J. Wheeler, I. K. Kamara, H. Johnson, J. E. Humphries, M. Zamanian, J. D. Chan
The paper screens macrocyclic lactones against Schistosoma flatworms using an automated imaging assay and lactate measurement, identifying compounds with antiparasitic activity but no in vivo efficacy.
bioRxiv · Sep 12, 2022Pharmacology & Toxicology