J. D. Chan

Development of non-sedating antischistosomal benzodiazepines

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

Phenotypic profiling of macrocyclic lactones on parasitic Schistosoma flatworms

The paper screens macrocyclic lactones against Schistosoma flatworms using an automated imaging assay and lactate measurement, identifying compounds with antiparasitic activity but no in vivo efficacy.

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

This study uses a multivariate screen to identify macrofilaricidal compounds, finding 17 compounds with strong effects on adult filariae and five with high potency against adults but low potency against microfilariae.

wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms

wrmXpress is a unified image analysis package for high-content phenotyping of parasitic and free-living worms, supporting multiple phenotypes and extensible with deep learning modules.

Schistosomes alter expression of immunomodulatory gene products following in vivo praziquantel exposure

This study investigates how praziquantel exposure affects Schistosoma mansoni gene expression in vivo, revealing up-regulation of immunomodulatory and anticoagulant gene products.

Praziquantel activates a schistosome transient receptor potential channel

This study identifies a transient receptor potential channel as the target of praziquantel in schistosomes and other PZQ-sensitive parasites.

Non-sedating benzodiazepines cause contractile paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni

This study identifies non-sedating benzodiazepines that cause contractile paralysis and tissue damage in Schistosoma mansoni, offering potential for new anti-schistosomal drugs with reduced host side effects.