M. Zamanian

Development of non-sedating antischistosomal benzodiazepines

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

Mapping resistance-associated anthelmintic interactions in the model nematode Caenorhabditis elegans

This study identifies how genetic mutations affecting drug entry routes in C. elegans alter anthelmintic susceptibility and drug interactions.

Phenotypic profiling of macrocyclic lactones on parasitic Schistosoma flatworms

The paper screens macrocyclic lactones against Schistosoma flatworms using an automated imaging assay and lactate measurement, identifying compounds with antiparasitic activity but no in vivo efficacy.

Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution.

This study uses single-cell analysis to identify the cellular origins of secretory products and anthelmintic responses in Brugia malayi microfilariae, revealing cell-specific expression patterns and introducing a cell culture model.

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

This study uses a multivariate screen to identify macrofilaricidal compounds, finding 17 compounds with strong effects on adult filariae and five with high potency against adults but low potency against microfilariae.

wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms

wrmXpress is a unified image analysis package for high-content phenotyping of parasitic and free-living worms, supporting multiple phenotypes and extensible with deep learning modules.

Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host

This paper shows that extracellular vesicles from Brugia malayi microfilariae reduce melanization in Aedes aegypti mosquitoes by downregulating AAEL002590 and decreasing phenoloxidase activity.

Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi

The paper uses spatial transcriptomics to identify antiparasitic targets in Brugia malayi head tissues, revealing new drug and vaccine candidates.

Genetic and functional diversification of chemosensory pathway receptors in filarial nematode parasites

This study identifies chemosensory receptors and ion channels in filarial worms and shows their role in migration and chemotaxis.