Author

K. T. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Organism:human· 1

Frequent Co-Authors

J. D. Chan· 4 shared M. Zamanian· 4 shared N. J. Wheeler· 3 shared K. J. Gallo· 2 shared S. S. Ericksen· 2 shared A. Y. Fedorov· 1 shared C. R. Henthorn· 1 shared D. Sharmin· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersPharmacology & Toxicology

J. D. Chan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of non-sedating antischistosomal benzodiazepines

M. Y. Mian, D. Sharmin, P. Mondal, J. B. Belayet, M. M. Hossain, P. McCusker, K. T. Ryan, A. Y. Fedorov, H. A. Green, S. S. Ericksen, M. Zamanian, V. V. N. Phani Babu Tiruveedhula, J. M. Cook, J. D. Chan

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

bioRxiv · Jan 26, 2024 · PreprintPharmacology & Toxicology

Phenotypic profiling of macrocyclic lactones on parasitic Schistosoma flatworms

K. T. Ryan, N. J. Wheeler, I. K. Kamara, H. Johnson, J. E. Humphries, M. Zamanian, J. D. Chan

The paper screens macrocyclic lactones against Schistosoma flatworms using an automated imaging assay and lactate measurement, identifying compounds with antiparasitic activity but no in vivo efficacy.

bioRxiv · Sep 12, 2022Pharmacology & Toxicology

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

N. J. Wheeler, K. T. Ryan, K. J. Gallo, C. R. Henthorn, S. S. Ericksen, J. D. Chan, M. Zamanian

This study uses a multivariate screen to identify macrofilaricidal compounds, finding 17 compounds with strong effects on adult filariae and five with high potency against adults but low potency against microfilariae.

bioRxiv · Jul 25, 2022 · PreprintMicrobiology

wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms

N. J. Wheeler, K. J. Gallo, E. J. Garncarz, K. T. Ryan, J. D. Chan, M. Zamanian

wrmXpress is a unified image analysis package for high-content phenotyping of parasitic and free-living worms, supporting multiple phenotypes and extensible with deep learning modules.

bioRxiv · May 18, 2022Microbiology