E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
G. Dewson, A. S. Huang, H. S. Chin, B. Reljic, T. M. Djajawi, I. K. Tan, D. A. Stroud, D. C. S. Huang, M. F. van Delft
This study identifies MARCHF5 as a regulator of BAK apoptotic activity through ubiquitin ligase activity, independent of BH3-only proteins, and shows its role in drug resistance.
bioRxiv · Jan 4, 2022 · PreprintCell Biology