Author

I. Kareva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Zutshi· 1 shared F. Berezovskaya· 1 shared G. Karev· 1 shared J. L. Gevertz· 1 shared J. Rhoden· 1 shared S. Kabilan· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 4 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Zutshi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

From hyperinsulinemia to cancer progression: how diminishing glucose storage capacity fuels insulin resistance

I. Kareva

The paper links hyperinsulinemia to cancer progression by showing how reduced glucose storage capacity leads to insulin resistance and affects tumor response to therapy.

bioRxiv · May 5, 2024Cancer Biology

Cytokine storm mitigation for exogenous immune agonists

I. Kareva, J. L. Gevertz

The paper develops a mathematical model to study cytokine storm risks in immune agonist therapies and identifies optimal dosing strategies to prevent storms while maintaining treatment efficacy.

bioRxiv · Jul 7, 2023Cancer Biology

Practical guide to calculating impact of avidity in models of bispecific antibodies with two membrane-bound targets

I. Kareva, S. Kabilan, A. Zutshi, J. Rhoden

The paper explains how to calculate avidity's impact in a mathematical model of bispecific antibodies targeting two membrane-bound proteins, supporting model-informed drug discovery.

bioRxiv · Sep 12, 2022 · PreprintPharmacology & Toxicology

Mathematical model of a cytokine storm

I. Kareva, F. Berezovskaya, G. Karev

This paper develops a mathematical model to simulate cytokine storm dynamics, identifying key factors that contribute to its occurrence and explaining individual variability in susceptibility.

bioRxiv · Feb 15, 2022 · PreprintImmunology