Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor resistant HER2-positive breast cancer
Q. Wang, I. M. Guldner, S. M. Golomb, L. Sun, J. Harris, X. Lu, S. Zhang
This study uses single-cell profiling to identify immunosuppressive cells in CDK4/6 inhibitor-resistant HER2+ breast cancer and shows that combinatorial immunotherapy can overcome resistance.
bioRxiv · Jun 14, 2019Cancer Biology