Author

I. Meewan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

R. Abagyan· 2 shared A. J. O'Donoghue· 1 shared A. Terskikh· 1 shared B. Woodworth· 1 shared C.-H. Chuang· 1 shared C.-T. Huang· 1 shared D. Skinner· 1 shared J. Kattoula· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

R. Abagyan

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Allosteric inhibitors of Zika virus NS2B-NS3 protease targeting protease in super-open conformation

I. Meewan, S. Shiryaev, C.-T. Huang, Y.-W. Lin, C.-H. Chuang, A. Terskikh, R. Abagyan

The paper identifies six allosteric inhibitors of ZIKV NS2B-NS3 protease targeting a super-open conformation pocket, showing low micromolar inhibition and antiviral activity.

bioRxiv · Mar 9, 2022Pharmacology & Toxicology

Discovery of Potent Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

I. Meewan, J. Kattoula, J. Kattoula, D. Skinner, P. Fajtov, M. Giardini, B. Woodworth, J. McKerrow, J. Siqueira-Neto, A. J. O'Donoghue, R. Abagyan

This paper identifies potent triple inhibitors targeting SARS-CoV-2 proteases and human cathepsin L, showing improved potency and antiviral effects compared to disulfiram.

bioRxiv · Oct 19, 2021Pharmacology & Toxicology