C.-T. Huang

Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

This study shows that neuritin modulates T cell electrical and metabolic states, influencing immune tolerance and immunity.

Allosteric inhibitors of Zika virus NS2B-NS3 protease targeting protease in super-open conformation

The paper identifies six allosteric inhibitors of ZIKV NS2B-NS3 protease targeting a super-open conformation pocket, showing low micromolar inhibition and antiviral activity.

Canonical BMP2/4 signaling degrades SOX2 in glioblastoma propagating cells.

This study shows BMP2/4 induces SOX2 degradation in glioblastoma propagating cells, leading to differentiation into glial cells and reduced proliferation.

Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells

This study identifies four conserved transcription factors that oppose cell fate reprogramming by controlling chromatin accessibility and gene expression, and shows their potential as therapeutic targets for regenerative medicine.

Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides

The paper develops an orally-administrable therapeutic using annexin A1-binding D-peptides to target tumor vasculature, showing suppression of brain tumor growth in mice.

Improving drug discovery using image-based multiparametric analysis of epigenetic landscape.

This paper introduces MIEL, an image-based method for epigenetic drug screening, showing it can detect active compounds, classify functions, and predict novel drug effects with higher resolution than traditional methods.