Author

S. Shiryaev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:virus· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Terskikh· 2 shared A. Cheltsov· 1 shared C.-H. Chuang· 1 shared C.-T. Huang· 1 shared I. Meewan· 1 shared P. Cieplak· 1 shared R. Abagyan· 1 shared R. C. Liddington· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

A. Terskikh

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

DUAL FUNCTION OF ZIKA VIRUS NS2B-NS3 PROTEASE

S. Shiryaev, P. Cieplak, A. Cheltsov, R. C. Liddington, A. Terskikh

This study identifies a novel RNA-binding function of ZIKV NS2B-NS3pro, showing that RNA binding occurs in the open conformation and is inhibited in the closed conformation.

PLOS Pathogens · Nov 27, 2023Peer-reviewedImmunology

Allosteric inhibitors of Zika virus NS2B-NS3 protease targeting protease in super-open conformation

I. Meewan, S. Shiryaev, C.-T. Huang, Y.-W. Lin, C.-H. Chuang, A. Terskikh, R. Abagyan

The paper identifies six allosteric inhibitors of ZIKV NS2B-NS3 protease targeting a super-open conformation pocket, showing low micromolar inhibition and antiviral activity.

bioRxiv · Mar 9, 2022Pharmacology & Toxicology