Author

I. Mougiakos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

J. van der Oost· 2 shared A. Carpentieri· 1 shared A. Gussak· 1 shared A. Illiano· 1 shared B. N. Gray· 1 shared C. L. Beisel· 1 shared D. J. Keiser· 1 shared E. F. Bosma· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

J. van der Oost

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA

O. Dmytrenko, G. Neumann, T. Hallmark, D. J. Keiser, V. M. Crowley, E. Vialetto, I. Mougiakos, K. G. Wandera, H. Domgaard, J. Weber, J. Metcalf, M. B. Begemann, B. N. Gray, R. N. Jackson, C. L. Beisel

This study shows that Cas12a2 causes abortive infection by degrading double-stranded DNA through RNA-triggered activity, and demonstrates its use as an RNA detection tool.

bioRxiv · Jun 13, 2022 · PreprintMicrobiology

A hyperthermoactive-Cas9 editing tool reveals the role of a unique arsenite methyltransferase in the arsenic resistance system of Thermus thermophilus HB27

G. Gallo, I. Mougiakos, M. Bianco, M. Carbonaro, A. Carpentieri, A. Illiano, P. Pucci, S. Bartolucci, J. van der Oost, G. Fiorentino

This paper identifies a novel arsenite methyltransferase in Thermus thermophilus and develops a hyperthermophilic Cas9-based genome-editing tool to study its role in arsenic resistance.

bioRxiv · Jul 12, 2021Biochemistry

Characterizing a thermostable Cas9 for bacterial genome editing and silencing

I. Mougiakos, P. Mohanraju, E. F. Bosma, V. Vrouwe, M. Finger Bou, M. I. S. Naduthodi, A. Gussak, R. B. L. Brinkman, R. van Kranenburg, J. van der Oost

This study identifies and characterizes ThermoCas9, a thermostable Cas9 variant active across a broad temperature range, and develops tools for bacterial genome editing and silencing at elevated temperatures.

bioRxiv · Aug 18, 2017Microbiology