Author

R. N. Jackson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 4 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:cryo-EM· 1

Frequent Co-Authors

C. L. Beisel· 2 shared D. W. Taylor· 2 shared H. Domgaard· 2 shared T. Hallmark· 2 shared A. Thomas· 1 shared B. N. Gray· 1 shared B. Naegle· 1 shared C. D. Cahoon· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

C. L. Beisel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CasDinG is an ATP-dependent 5'-3' DNA helicase with accessory domains essential for type IV CRISPR immunity

H. Domgaard, C. D. Cahoon, M. Armbrust, O. Redman, A. Thomas, R. N. Jackson

bioRxiv · Aug 23, 2022 · PreprintBiochemistry

Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA

O. Dmytrenko, G. Neumann, T. Hallmark, D. J. Keiser, V. M. Crowley, E. Vialetto, I. Mougiakos, K. G. Wandera, H. Domgaard, J. Weber, J. Metcalf, M. B. Begemann, B. N. Gray, R. N. Jackson, C. L. Beisel

This study shows that Cas12a2 causes abortive infection by degrading double-stranded DNA through RNA-triggered activity, and demonstrates its use as an RNA detection tool.

bioRxiv · Jun 13, 2022 · PreprintMicrobiology

Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2

J. P. Bravo, T. Hallmark, B. Naegle, C. L. Beisel, R. N. Jackson, D. W. Taylor

The paper reports structures of Cas12a2 to elucidate its activation pathway and mechanism of indiscriminate nuclease activity against various substrates.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry

Structure of a type IV CRISPR-Cas effector complex

Y. Zhou, J. P. K. Bravo, H. N. Taylor, J. Steens, R. N. Jackson, R. H. J. Staals, D. W. Taylor

The paper determines the structure of a type IV-B CRISPR-Cas effector complex using cryo-EM, revealing its unique assembly and function.

bioRxiv · Jul 31, 2020 · PreprintBiochemistry