Author

I. Nassiri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. P. Fairfax· 2 shared B. Sun· 2 shared M. R. Middleton· 2 shared O. Tong· 2 shared P. K. Sharma· 2 shared R. A. Cooper· 2 shared R. A. Watson· 2 shared A. de los Aires· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersImmunology

B. P. Fairfax

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Author profile →

3 papers

Recent·Most cited

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

S. Sivakumar, A. Jainarayanan, E. Arbe-Barnes, M. N. Leathlobhair, P. K. Sharma, S. Amin, L. Heij, S. Hegde, A. Magen, F. Tucci, B. Sun, S. Wu, N. M. Anand, H. Slawinski, S. Revale, , R. J. M. Bashford-Rogers

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

bioRxiv · Aug 31, 2023 · PreprintImmunology

Deep sequencing of the T cell Receptor reveals common and reproducible CD8+ signatures of response to checkpoint immunotherapy

R. A. Watson, C. Taylor, O. Tong, R. A. Cooper, E. Jungkurth, P. Kumar Sharma, B. Storey, W. Ye, B. Sun, A. de los Aires, F. Matos Santo, I. Nassiri, J. Gilchrist, E. Ieremia, M. R. Middleton, B. P. Fairfax

The paper uses TCR sequencing to identify CD8+ T cell clones associated with response to checkpoint immunotherapy in metastatic melanoma, finding a correlation between peripheral ER clone proportion and clinical outcome.

bioRxiv · Feb 11, 2023 · PreprintImmunology

Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8+ T cell clone size and cytotoxicity

R. A. Watson, O. Tong, R. A. Cooper, C. A. Taylor, P. K. Sharma, A. Verge de los Aires, E. Mahe, H. Ruffieux, I. Nassiri, M. R. Middleton, B. P. Fairfax

The paper uses single-cell and bulk RNA sequencing to show that CD8+ T cell subset and clone size influence gene expression responses to immune checkpoint blockade, and that pre-treatment cytotoxicity and clonality predict progression-free survival.

bioRxiv · Nov 15, 2020 · PreprintImmunology