R. A. Watson

Natural Induction: Spontaneous adaptive organisation without natural selection

This paper demonstrates that spontaneous adaptive organisation can arise from the interaction of physical optimisation and learning in dynamical systems, without natural selection.

An ability to respond begins with inner alignment: How phase synchronisation effects transitions to higher levels of agency

The paper uses computational models to show how phase synchronisation of microscale agents leads to emergent higher-level agency through increased problem-solving competency.

Deep sequencing of the T cell Receptor reveals common and reproducible CD8+ signatures of response to checkpoint immunotherapy

The paper uses TCR sequencing to identify CD8+ T cell clones associated with response to checkpoint immunotherapy in metastatic melanoma, finding a correlation between peripheral ER clone proportion and clinical outcome.

Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8+ T cell clone size and cytotoxicity

The paper uses single-cell and bulk RNA sequencing to show that CD8+ T cell subset and clone size influence gene expression responses to immune checkpoint blockade, and that pre-treatment cytotoxicity and clonality predict progression-free survival.

Identifying causes of social evolution: The Price approach, contextual analysis, and multilevel selection

The paper compares two statistical methods for analyzing group selection in social evolution and argues that multilevel selection theory provides a more accurate causal framework.

Developmental models reveal the role of phenotypic plasticity in explaining genetic evolvability

The paper uses developmental models to show that phenotypic plasticity and genetic evolvability co-evolve, with plasticity providing faster adaptive gains.

How adaptive plasticity evolves when selected against

This study shows adaptive plasticity can evolve in coarse-grained environments as a by-product of inefficient short-term selection, not through lineage or individual selection.