Author

H. Ruffieux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein structure prediction· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. Verge de los Aires· 1 shared B. P. Fairfax· 1 shared C. A. Taylor· 1 shared E. Mahe· 1 shared I. Nassiri· 1 shared M. R. Middleton· 1 shared O. Tong· 1 shared P. K. Sharma· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

A. Verge de los Aires

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1 paper

Recent·Most cited

Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8+ T cell clone size and cytotoxicity

R. A. Watson, O. Tong, R. A. Cooper, C. A. Taylor, P. K. Sharma, A. Verge de los Aires, E. Mahe, H. Ruffieux, I. Nassiri, M. R. Middleton, B. P. Fairfax

The paper uses single-cell and bulk RNA sequencing to show that CD8+ T cell subset and clone size influence gene expression responses to immune checkpoint blockade, and that pre-treatment cytotoxicity and clonality predict progression-free survival.

bioRxiv · Nov 15, 2020 · PreprintImmunology