Author

R. A. Cooper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. P. Fairfax· 2 shared I. Nassiri· 2 shared M. R. Middleton· 2 shared O. Tong· 2 shared R. A. Watson· 2 shared A. C. Aguiar· 1 shared A. Churchyard· 1 shared A. de los Aires· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

B. P. Fairfax

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Deep sequencing of the T cell Receptor reveals common and reproducible CD8+ signatures of response to checkpoint immunotherapy

R. A. Watson, C. Taylor, O. Tong, R. A. Cooper, E. Jungkurth, P. Kumar Sharma, B. Storey, W. Ye, B. Sun, A. de los Aires, F. Matos Santo, I. Nassiri, J. Gilchrist, E. Ieremia, M. R. Middleton, B. P. Fairfax

The paper uses TCR sequencing to identify CD8+ T cell clones associated with response to checkpoint immunotherapy in metastatic melanoma, finding a correlation between peripheral ER clone proportion and clinical outcome.

bioRxiv · Feb 11, 2023 · PreprintImmunology

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

L. E. de Vries, P. A. Jansen, C. Barcelo, J. Munro, J. M. Verhoef, C. F. A. Pasaje, K. Rubiano, J. Striepen, J. M. Bolscher, R. Henderson, T. Huijs, K. M. Koolen, P. K. Tumwebaze, T. Yeo, A. C. Aguiar, , K. J. Dechering

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

bioRxiv · May 12, 2021Microbiology

Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8+ T cell clone size and cytotoxicity

R. A. Watson, O. Tong, R. A. Cooper, C. A. Taylor, P. K. Sharma, A. Verge de los Aires, E. Mahe, H. Ruffieux, I. Nassiri, M. R. Middleton, B. P. Fairfax

The paper uses single-cell and bulk RNA sequencing to show that CD8+ T cell subset and clone size influence gene expression responses to immune checkpoint blockade, and that pre-treatment cytotoxicity and clonality predict progression-free survival.

bioRxiv · Nov 15, 2020 · PreprintImmunology