Author

I. Pertici

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1 Organism:rat· 1 Assay:structural biology· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

P. Bianco· 3 shared G. Bianchi· 2 shared M. Caremani· 2 shared M. Reconditi· 2 shared V. Lombardi· 2 shared A. V. Kashchuk· 1 shared C. Arbore· 1 shared F. S. Pavone· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

P. Bianco

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Author profile →

4 papers

Recent·Most cited

An integrated picture of the structural pathways controlling the heart performance

I. Morotti, M. Caremani, M. Marcello, I. Pertici, P. Bianco, N. Theyencheri, G. Piazzesi, M. Reconditi, V. Lombardi, M. Linari

The paper revises the mechanosensing hypothesis of heart function using X-ray diffraction data and cryo-EM structures, identifying structural changes in thick filaments that modulate motor activation and heart performance.

Proceedings of the National Academy of Sciences · Dec 10, 2024Peer-reviewedPhysiology

A myosin II-based nanomachine devised for the study of Ca2+-dependent mechanisms of muscle regulation

I. Pertici, G. Bianchi, L. Bongini, V. Lombardi, P. Bianco

This paper describes a synthetic nanomachine using myosin II and actin to study Ca2+-dependent muscle regulation mechanisms, showing consistent power output across Ca2+ concentrations.

bioRxiv · Sep 5, 2020Biophysics

α-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity

C. Arbore, M. Sergides, L. Gardini, G. Bianchi, A. V. Kashchuk, I. Pertici, P. Bianco, F. S. Pavone, M. Capitanio

This study shows that -catenin forms different types of bonds with F-actin depending on its dimerization state and applied force, affecting cell junction fluidity.

bioRxiv · Apr 15, 2020Biophysics

A mechanical model of the half-sarcomere which includes the contribution of titin

I. Pertici, M. Caremani, M. RECONDITI

The paper develops a mechanical model of the half-sarcomere that incorporates titin's contribution to address discrepancies in compliance predictions from the 1981 Huxley model.

bioRxiv · Nov 9, 2018Biophysics