I. R. Nabi

nERdy: network analysis of endoplasmic reticulum dynamics

nERdy and nERdy+ accurately extract and represent ER network dynamics, revealing roles of Atlastin and Reticulon 4 in tubular matrix formation.

Membrane contact site detection (MCS-DETECT) reveals dual control of rough mitochondria-ER contacts

MCS-DETECT identifies a dual regulatory mechanism for riboMERCs, dependent on RRBP1 and modulated by Gp78 ubiquitin ligase activity.

Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS production

This study shows that basal Gp78-dependent mitophagy maintains mitochondrial health by removing low-potential mitochondria, thereby reducing ROS production.

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

This paper identifies N-0385 as a potent inhibitor of TMPRSS2 that blocks SARS-CoV-2 variants and protects mice from infection and mortality.

SUPER RESOLUTION MICROSCOPY AND DEEP LEARNING IDENTIFY ZIKA VIRUS REORGANIZATION OF THE ENDOPLASMIC RETICULUM

This study uses super resolution microscopy and deep learning to identify ZIKV-induced ER reorganization and its role in viral replication.

Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules

This study shows reticulon and CLIMP-63 regulate nanodomain organization and dynamics of peripheral ER tubules through STED microscopy and live imaging.

Super-resolution modularity analysis shows polyhedral caveolin-1 oligomers combine to form scaffolds and caveolae

The paper uses super-resolution microscopy and network modularity analysis to show that caveolin-1 oligomers form modular scaffolds and caveolae through polyhedral interactions.