G. Gao

Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer's disease

This study identifies axonal enlargement linked to amyloidosis, lysosome destabilization, and hemorrhage as a key pathological feature in Alzheimer's disease.

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

Nanoscale domains govern local diffusion and aging within FUS condensates

This study uses single-molecule tracking to show that nanodomains within FUS condensates regulate diffusion and aging, influencing fibrilization and disease progression.

nERdy: network analysis of endoplasmic reticulum dynamics

nERdy and nERdy+ accurately extract and represent ER network dynamics, revealing roles of Atlastin and Reticulon 4 in tubular matrix formation.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Successful spread of mcr-1-bearing IncX4 plasmids is associated with variant in replication protein of IncX4 plasmids

The paper shows that IncX4 plasmids with pir-1 have higher mcr-1 expression and fitness burden but lower invasion rates compared to pir-2 plasmids, explaining why mcr-1 is absent from pir-2 plasmids.

The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability

This study identifies STUB1 as a tumor suppressor in ccRCC by promoting YTHDF1 degradation, with low STUB1 expression linked to poor patient outcomes.

An end-to-end workflow for non-destructive 3D pathology

This paper provides an end-to-end workflow for non-destructive 3D pathology using light-sheet microscopy, focusing on fluorescent H&E analogs for preclinical and clinical studies.

Aβ-aggregation-generated blue autofluorescence illuminates senile plaques, complex blood and vascular pathologies in the Alzheimer's disease

The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

This study identifies BTRC as an E3 ligase that promotes ATGL proteasomal degradation, contributing to hepatic steatosis in NAFLD, and suggests BTRC as a potential therapeutic target.

Potential limitations of micro-dystrophin gene therapy for Duchenne muscular dystrophy

This study evaluates micro-dystrophin gene therapy in a DMD mouse model, finding cardiac disease acceleration with one micro-dystrophin and potential benefits with another, highlighting the need for careful dosing.

Membrane contact site detection (MCS-DETECT) reveals dual control of rough mitochondria-ER contacts

MCS-DETECT identifies a dual regulatory mechanism for riboMERCs, dependent on RRBP1 and modulated by Gp78 ubiquitin ligase activity.

Plant-on-Chip: core morphogenesis processes in the tiny plant Wolffia australiana

This paper introduces Wolffia australiana as a model system for studying plant morphogenesis using a Plant-on-Chip culture system and advanced technologies like snRNA-seq.

Fish oil Nano-emulsion Kills Macrophage: Ferroptosis and Autophagy Triggered by Catalase-catalysed Superoxide Eruption

The paper shows fish oil nano-emulsions trigger ferroptosis and autophagy in macrophages via catalase-catalyzed superoxide production, leading to oxidative damage.

OsMADS58 stabilizes gene regulatory circuits during rice stamen development

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS production

This study shows that basal Gp78-dependent mitophagy maintains mitochondrial health by removing low-potential mitochondria, thereby reducing ROS production.

Insulin receptor trafficking and interactions in muscle cells

This study investigates insulin receptor trafficking and interactions in muscle cells, identifying caveolin and clathrin-mediated pathways involved in receptor dynamics.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

This paper identifies N-0385 as a potent inhibitor of TMPRSS2 that blocks SARS-CoV-2 variants and protects mice from infection and mortality.

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

Senile plaques in Alzheimer's disease arise from Aβ and Cathepsin D-enriched amyloidogenic mixtures out of intravascular hemolysis and Charcot-Bouchard aneurysm-related vascular degeneration

This study identifies that senile plaques in Alzheimer's disease originate from Aβ and Cathepsin D-enriched amyloid mixtures formed through intravascular hemolysis and vascular degeneration.

SUPER RESOLUTION MICROSCOPY AND DEEP LEARNING IDENTIFY ZIKA VIRUS REORGANIZATION OF THE ENDOPLASMIC RETICULUM

This study uses super resolution microscopy and deep learning to identify ZIKV-induced ER reorganization and its role in viral replication.

A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

Diversity and Structural Variability of Bacterial Microbial Communities in Rhizocompartments of Desert Leguminous Plants

This study examines bacterial community diversity and structure across different rhizocompartments of desert leguminous plants, revealing significant niche-driven variability and core microbiomes.

Golgi SM protein Sly1 promotes productive trans-SNARE complex assembly through multiple mechanisms

The paper identifies three mechanisms by which Sly1 enhances SNARE-mediated membrane fusion and shows that close-range tethering is crucial when cis-SNARE assembly competes.

The use of high throughput phenotyping for assessment of heat stress-induced changes in Arabidopsis

This study uses high-throughput phenotyping to identify heat stress-induced changes in Arabidopsis, finding that 6h of heat stress provides the most informative insights into plant responses.

Multiple features within Sed5p mediate it’s COPI-independent trafficking and Golgi localization

This study identifies that Sed5p's Golgi localization and trafficking are COPI-independent and rely on conformational associations between its Habc domain and SNARE-motif.