Author

D. W. Buchholz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

A. August· 2 shared B. Imbiakha· 2 shared H. C. Aguilar· 2 shared X. Chen· 2 shared A. Chin· 1 shared A. D. Olmstead· 1 shared A. Desilets· 1 shared A. T. Tang· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersPathology

A. August

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3 papers

Recent·Most cited

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice

S. Gao, A. T. Tang, M. Wang, D. W. Buchholz, B. Imbiakha, J. Yang, X. Chen, P. Hewins, P. Mericko-Ishizuka, N. A. Leu, S. Sterling, A. August, K. Jurado, E. Morrisey, H. Aguilar-Carreno, M. L. Kahn

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

bioRxiv · Jul 24, 2023 · PreprintPathology

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

T. Shapira, I. A. Monreal, S. P. Dion, M. Jager, A. Desilets, A. D. Olmstead, T. Vandal, D. W. Buchholz, B. Imbiakha, G. Gao, A. Chin, W. D. Rees, T. Steiner, I. R. Nabi, E. Marsault, , F. Jean

This paper identifies N-0385 as a potent inhibitor of TMPRSS2 that blocks SARS-CoV-2 variants and protects mice from infection and mortality.

bioRxiv · May 3, 2021 · PreprintMicrobiology

The effects of modified sialic acids on mucus and erythrocytes on influenza A virus HA and NA functions

K. N. Barnard, B. K. Alford-Lawrence, D. W. Buchholz, B. R. Wasik, J. R. LaClair, H. Yu, R. Honce, S. Ruhl, P. Pajic, E. K. Daugherity, X. Chen, S. Schultz-Cherry, H. C. Aguilar, A. Varki, C. R. Parrish

This study examines how modified sialic acids in mucus and erythrocytes affect influenza A virus HA and NA functions, finding that these modifications inhibit viral binding and cleavage.

bioRxiv · Oct 10, 2019 · PreprintMicrobiology