Notch engagement by Jag1 nanoscale clusters indicates a force-independent mode of activation
I. Smyrlaki, F. Fördös, I. Rocamonde Lago, Y. Wang, A. Lentini, V. C. Luca, B. Reinius, A. I. Teixeira, B. Högberg
This study shows that Notch receptors can be activated by multivalent Jag1 ligand clusters without requiring mechanical force, using iPSc-derived cells and DNA origami patterns.
bioRxiv · Nov 22, 2022Cell Biology