Author

V. C. Luca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Antfolk· 2 shared A. I. Teixeira· 1 shared A. Lentini· 1 shared A. Necakov· 1 shared A. Turgambayeva· 1 shared B. Högberg· 1 shared B. Reinius· 1 shared C. Jiang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

D. Antfolk

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping.

G. Foran, R. D. Hallam, M. Megaly, A. Turgambayeva, D. Antfolk, Y. Li, V. C. Luca, A. Necakov

This study shows that Notch1's N1ICD forms transcriptional condensates via phase separation coupled percolation, enhancing target gene expression and enhancer looping.

bioRxiv · Mar 17, 2023Cell Biology

Notch engagement by Jag1 nanoscale clusters indicates a force-independent mode of activation

I. Smyrlaki, F. Fördös, I. Rocamonde Lago, Y. Wang, A. Lentini, V. C. Luca, B. Reinius, A. I. Teixeira, B. Högberg

This study shows that Notch receptors can be activated by multivalent Jag1 ligand clusters without requiring mechanical force, using iPSc-derived cells and DNA origami patterns.

bioRxiv · Nov 22, 2022Cell Biology

An affinity-matured DLL4 ligand for broad-spectrum activation and inhibition of Notch signaling

D. Gonzalez-Perez, S. Das, E. Medina, D. Antfolk, E. D. Egan, S. C. Blacklow, P. C. Rodriguez, V. C. Luca

This study develops DeltaMAX, an affinity-matured DLL4 ligand that broadly activates or inhibits Notch signaling in human and murine systems.

bioRxiv · Mar 7, 2022 · PreprintBioengineering

Structural basis of bile acid receptor activation and Gs coupling

F. Yang, C. Mao, L. Guo, J. Lin, Q. Ming, P. Xiao, X. Wu, Q. Shen, S. Guo, D.-D. Shen, R. Lu, L. Zhang, S. Huang, Y. Ping, C. Zhang, , Y. Zhang

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

bioRxiv · May 24, 2020 · PreprintBiochemistry