Author

B. Högberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Fördös· 2 shared I. Smyrlaki· 2 shared Y. Wang· 2 shared A. I. Teixeira· 1 shared A. Lentini· 1 shared A. Shaw· 1 shared B. Reinius· 1 shared I. Baars· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCell Biology

F. Fördös

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Notch engagement by Jag1 nanoscale clusters indicates a force-independent mode of activation

I. Smyrlaki, F. Fördös, I. Rocamonde Lago, Y. Wang, A. Lentini, V. C. Luca, B. Reinius, A. I. Teixeira, B. Högberg

This study shows that Notch receptors can be activated by multivalent Jag1 ligand clusters without requiring mechanical force, using iPSc-derived cells and DNA origami patterns.

bioRxiv · Nov 22, 2022Cell Biology

Clustering of death receptor for apoptosis using nanoscale patterns of peptides

Y. Wang, I. Baars, F. Fördös, B. Högberg

The paper uses DNA origami to pattern TRAIL-mimicking peptides at nanoscale distances, finding that 5 nm spacing induces death receptor clustering and apoptosis in breast cancer cells.

bioRxiv · Nov 16, 2020Bioengineering

The geometric determinants of programmed antibody migration and binding on multi-antigen substrates

I. T. Hoffecker, A. Shaw, V. Sorokina, I. Smyrlaki, B. Högberg

The paper develops a model to simulate antibody-antigen interactions on patterned surfaces and shows antigen spacing influences antibody migration and binding.

bioRxiv · Oct 12, 2020 · PreprintBiophysics