Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in Plasmodium falciparum
M. Raghavan, K. L. Kalantar, E. Duarte, N. Teyssier, S. Takahashi, A. F. Kung, J. V. Rajan, J. Rek, K. K. A. Tetteh, C. Drakeley, I. Ssewanyana, I. Rodriguez-Barraquer, B. Greenhouse, J. L. DeRisi
The paper profiles antibody responses to Plasmodium falciparum antigens in Ugandan cohorts, finding that repeat-containing antigens show stronger exposure-dependent responses and shared cross-reactive motifs.
bioRxiv · Jun 24, 2022Immunology