S. Takahashi

Decrease in Purifying Selection Pressures on Wheat Homoeologous Genes: Tetraploidization vs Hexaploidization

The paper compares the impact of tetraploidization and hexaploidization on selection pressures of homoeologous genes in wheat, finding tetraploidization has a greater effect.

vmTracking: Virtual Markers Overcome Occlusion and Crowding in Multi-Animal Pose Tracking

vmTracking uses virtual markers to improve multi-animal pose tracking by overcoming occlusion and crowding with minimal manual correction.

Functional studies of deafness-associated pendrin and prestin variants

The paper functionally characterizes deafness-associated pendrin and prestin variants using in vitro assays to assess their pathogenic impacts.

Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation

The paper identifies Dusp13 and Dusp27 as MYOD target genes that regulate muscle stem cell transition from proliferation to differentiation during myogenesis.

The molecular principles underlying diverse functions of the SLC26 family of proteins

This study identifies common and distinct molecular mechanisms among SLC26 proteins using mutations in SLC26A4, SLC26A5, and SLC26A9.

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

Isogenic iPSC-derived proximal and distal lung-on-chip models: Tissue- and virus-specific immune responses in human lungs

The paper develops isogenic lung-on-chip models from iPSC-derived cells to study tissue-specific immune responses to SARS-CoV-2 and Influenza viruses.

Heart generation via blastocyst complementation in Mesp1/2-deficient mice

This study generates functional adult hearts in Mesp1/2-deficient mice using blastocyst complementation with pluripotent stem cells, showing successful derivation of all cardiovascular lineages from exogenous cells.

The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing loss

This study investigates the pathogenic effects of the p.R130S prestin variant in DFNB61 hearing loss, showing it causes progressive outer hair cell loss and reduced motor kinetics.

Label-free ghost cytometry for manufacturing of cell therapy products

This paper introduces label-free ghost cytometry (LF-GC) for cell therapy manufacturing, showing it can quantify cell count, viability, and identify cell subsets and impurities without staining.

The influence of river discharge on gravel bar hyporheic microbial community structure and putative metabolic functions.

This study examines how river discharge affects microbial community structure and metabolic functions in hyporheic zones of gravel bars.

Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice

This study shows that Prdm13 signaling in the dorsomedial hypothalamus affects age-related sleep-wake changes in mice, and dietary restriction can mitigate these effects.

Experimental determination and mathematical modeling of standard shapes of forming autophagosomes

The paper determines the average shapes of forming autophagosomes using 3D electron microscopy and develops a model showing their morphology is determined by the ratio of rim size to surface area.

Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

The paper shows that low pH triggers cellulase-mediated release of monosaccharides from algal cell walls in coral symbionts.

Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in Plasmodium falciparum

The paper profiles antibody responses to Plasmodium falciparum antigens in Ugandan cohorts, finding that repeat-containing antigens show stronger exposure-dependent responses and shared cross-reactive motifs.

Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer

Reduction of susceptibility to azoles and 5-fluorocytosine and growth acceleration in Candida albicans by glucose in urine

This study shows that high glucose levels in urine promote Candida albicans growth and reduce susceptibility to azoles and 5-fluorocytosine.

Reconstitution of prenyltransferase activity on nanodiscs by components of the rubber synthesis machinery of the Para rubber tree and guayule

The paper reconstitutes prenyltransferase activity using proteins from Para rubber tree and guayule in nanodiscs, showing that HRT1 and HRBP form an active complex.

TAZ/TEAD complex regulates TGF-β1-mediated fibrosis in iPSC-derived renal organoids

This study shows that INT-767 prevents fibrosis in iPSC-derived renal organoids by modulating the TEAD4/TAZ pathway.

Evaluation of solvents used for fabrication of microphysiological systems

This study evaluates solvent use in microphysiological systems fabrication, showing that solvent bonding harms cell cultures while photobonding avoids these issues.

SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication

This study shows SAF-A promotes DNA replication by enhancing origin licensing and fork progression, preventing replication defects and cell quiescence.

The Conserved Colletotrichum spp. Effector CEC3 Induces Nuclear Expansion and Cell Death in Plants

This study identifies CEC3 as a conserved effector in Colletotrichum fungi that induces nuclear expansion and cell death in plants, supporting its role in the hemibiotrophic lifestyle.

Molecular basis for two stereoselective Diels-Alderases that produce decalin skeletons

This study determines the molecular mechanisms of two Diels-Alderases that produce enantiomeric decalin scaffolds through structural and computational analyses.

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

This study identifies the HBO1-MLL interaction as critical for leukemogenesis by facilitating the AF4/ENL/P-TEFb complex-mediated gene activation in MLL fusion proteins.

Genome-wide analysis of long noncoding RNAs, 24-nt siRNAs, DNA methylation and H3K27me3 marks in Brassica rapa and related species

This study analyzes lncRNAs, 24-nt siRNAs, DNA methylation, and H3K27me3 in Brassica rapa and related species to understand their epigenetic interactions and conservation patterns.

HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

This study shows HOXA9 promotes MYC-driven leukemogenesis by maintaining anti-apoptotic gene expression through multiple pathways.

Species-specific phototaxis of coral larvae causes variation in vertical positioning during dispersal

The paper shows that P. verrucosa coral larvae use phototaxis to position themselves near the surface, while other species do not.

Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

This study sequenced the genome of a kleptoplastic sea slug and found no evidence of algal gene transfer to the nucleus, showing photosynthesis can occur without nuclear gene transfer.

Spatially Varying Trophic Effects of Reservoir-Derived Plankton on Stream Macroinvertebrates Among Heterogeneous Habitats Within Reaches

This study assesses how reservoir-derived plankton affect stream macroinvertebrates in different habitats, finding lower trophic contributions in lentic habitats compared to lotic ones.