B. Greenhouse

Broadly inhibitory antibodies against severe malaria virulence proteins

The paper identifies two human monoclonal antibodies that broadly inhibit PfEMP1's binding to EPCR, a key process in severe malaria pathogenesis.

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.

Atypical B cells consist of subsets with distinct effector functions

The paper identifies three distinct subsets of atypical B cells with unique transcriptional and functional profiles in individuals with chronic Plasmodium falciparum exposure.

Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in Plasmodium falciparum

The paper profiles antibody responses to Plasmodium falciparum antigens in Ugandan cohorts, finding that repeat-containing antigens show stronger exposure-dependent responses and shared cross-reactive motifs.

Age dependent changes in circulating Tfh cells influence the development of functional antibodies to malaria in children.

The paper examines age-related changes in Tfh cells and their impact on antibody development against malaria in children, finding age-dependent shifts in Tfh cell subsets and antibody responses.

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

Plasmodium falciparum serology: A comparison of two protein production methods for analysis of antibody responses by protein microarray

This study compares antibody responses to proteins produced by IVTT and purified recombinant systems on a protein microarray, finding greater responses to purified recombinants and variable correlation between expression systems.

Impact of a rapid decline in malaria transmission on antimalarial IgG subclasses and avidity

The paper examines how malaria transmission decline affects antimalarial IgG subclasses and avidity in Ugandans, finding age-related changes in IgG decay, subclass ratios, and avidity dynamics.

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.

Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda

This study quantifies household and spatial variation in malaria vector exposure using Bayesian modeling in three Ugandan sites, identifying hotspots linked to environmental factors and seasonal changes.