Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype
I. S. Fonseca, C. Horta, A. S. Ribeiro, B. Sousa, G. Marteil, M. Bettencourt Dias, J. Paredes
This study shows Plk4 promotes anoikis resistance in p53KO mammary epithelial cells through a hybrid EMT phenotype and P-cadherin upregulation, acting as an oncogene independent of centrosome biogenesis.
bioRxiv · Dec 16, 2022 · PreprintCancer Biology