J. Paredes

Deciphering the impact of cancer cells secretome and its derived-peptide VGF on breast cancer brain metastasis

This study identifies VGF as a key mediator in breast cancer brain metastasis, showing its association with poor prognosis and BBB disruption.

Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype

This study shows Plk4 promotes anoikis resistance in p53KO mammary epithelial cells through a hybrid EMT phenotype and P-cadherin upregulation, acting as an oncogene independent of centrosome biogenesis.

Detergent-Free Decellularization Preserves the Structural and Biological Integrity of Murine Tendon

This paper introduces a detergent-free decellularization method for murine tendon that preserves structural and biological integrity, demonstrating its effectiveness across different mouse strains and tendon types.

Activation of the actin/MRTF-A/SRF signalling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation

This study identifies P-cadherin's role in activating the actin/MRTF-A/SRF pathway in pre-malignant mammary cells, essential for early breast cancer progression.

Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 promotes tumour growth

The paper shows that discontinuous TGFβ1 exposure induces EMT/MET transitions in EpH4 cells, leading to RE-cells with molecular and functional heterogeneity that promotes tumour growth.