B. Sousa

PERK inhibition with GSK2606414 in zebrafish evokes developmental defects consistent with Wolcott-Rallison syndrome phenotypes

This study uses zebrafish to model Wolcott-Rallison syndrome by inhibiting PERK with GSK2606414, revealing developmental defects consistent with the syndrome.

Molten globule driven and self-downmodulated phase separation of a viral factory scaffold

The paper shows that the viral protein P undergoes phase separation driven by a molten globule domain and self-downmodulation, forming viral factories through nucleation-condensation with nucleoprotein N.

Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype

This study shows Plk4 promotes anoikis resistance in p53KO mammary epithelial cells through a hybrid EMT phenotype and P-cadherin upregulation, acting as an oncogene independent of centrosome biogenesis.