Author

I. Sadowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

R. Horvath· 2 shared Z. L. Brumme· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

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2 shared papersMicrobiology

R. Horvath

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2 papers

Recent·Most cited

Small molecule inhibitors of transcriptional Cyclin Dependent Kinases impose HIV-1 latency, presenting "block and lock" treatment strategies

R. Horvath, Z. L. Brumme, I. Sadowski

The paper shows that small molecule inhibitors of CDK7, CDK9, and CDK8/19 can induce HIV-1 latency, with CDK8/19 inhibitors maintaining latency after drug removal.

bioRxiv · Aug 17, 2023Microbiology

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

R. Horvath, Z. L. Brumme, I. Sadowski

This study shows CDK8/19 inhibitors reduce HIV-1 reactivation and enhance provirus latency in T cells by impairing RNA Pol II recruitment to the HIV-1 LTR.

bioRxiv · Jun 7, 2023 · PreprintMicrobiology