Author

Z. L. Brumme

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

I. Sadowski· 2 shared R. Horvath· 2 shared A. Shahid· 1 shared A. Trocha· 1 shared B. D. Walker· 1 shared B. R. Jones· 1 shared C. J. Brumme· 1 shared D. MacMillan· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

I. Sadowski

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Small molecule inhibitors of transcriptional Cyclin Dependent Kinases impose HIV-1 latency, presenting "block and lock" treatment strategies

R. Horvath, Z. L. Brumme, I. Sadowski

The paper shows that small molecule inhibitors of CDK7, CDK9, and CDK8/19 can induce HIV-1 latency, with CDK8/19 inhibitors maintaining latency after drug removal.

bioRxiv · Aug 17, 2023Microbiology

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

R. Horvath, Z. L. Brumme, I. Sadowski

This study shows CDK8/19 inhibitors reduce HIV-1 reactivation and enhance provirus latency in T cells by impairing RNA Pol II recruitment to the HIV-1 LTR.

bioRxiv · Jun 7, 2023 · PreprintMicrobiology

HIV proviral burden, genetic diversity and dynamics in viremic controllers who subsequently initiated suppressive antiretroviral therapy

F. H. Omondi, H. Sudderuddin, A. Shahid, N. N. Kinloch, B. R. Jones, R. L. Miller, O. Tsai, D. MacMillan, A. Trocha, M. A. Brockman, C. J. Brumme, J. B. Joy, R. Liang, B. D. Walker, Z. L. Brumme

This study characterizes proviral burden, diversity, and dynamics in viremic controllers before and after ART initiation using phylogenetic analysis and mathematical modeling.

bioRxiv · Mar 29, 2021Microbiology