Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells
N. T. Awatade, S. L. Wong, E. Pandzic, I. Slapetova, A. Capraro, L. Zhong, N. Turgutoglu, L. K. Fawcett, R. Whan, A. Jaffe, S. Waters
The paper compares functional differences between two culture methods for nasal epithelial cells and finds significant variations in barrier integrity and CFTR-mediated chloride currents despite similar morphology and proteomics.
bioRxiv · May 29, 2020Physiology