E. Pandzic

ApoA-I Protects Pancreatic β-cells from Cholesterol-induced Mitochondrial Damage and Restores their Ability to Secrete Insulin

This study shows apoA-I improves β-cell insulin secretion by reducing oxidative stress and enhancing mitochondrial function in cholesterol-loaded cells.

βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer

This study identifies βIII-tubulin as a suppressor of extrinsic apoptosis in pancreatic cancer, showing that its silencing enhances sensitivity to death signals and reduces tumor progression.

Longitudinal characterisation of phagocytic and neutralisation functions of anti-Spike antibodies in plasma of patients after SARS-CoV-2 infection.

This study shows that phagocytic and neutralisation functions of anti-Spike antibodies persist in SARS-CoV-2 convalescents despite declining antibody titers, with improved antibody affinity correlating with maintained effector functions.

Defined microenvironments trigger in vitro gastrulation in human pluripotent stem cells

This study shows that microconfinement of pluripotent stem cells on hydrogels triggers gastrulation-like events without exogenous factors, leading to primitive streak formation and lineage specification.

Spatial-temporal analysis of nanoparticles in live tumor spheroids impacted by cell origin and density

This paper develops a platform to analyze nanoparticle uptake in 3D tumor spheroids, showing uptake inversely relates to particle size and varies with cell type and spheroid density.

Tropomyosin isoforms segregate into distinct clusters on single actin filaments

This study shows that tropomyosin isoforms form distinct clusters on actin filaments due to their sequence similarity, not actin isoform preference.

Ageing impairs the airway epithelium defence response to SARS-CoV-2

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

Bringing the pancreas patient back to the bench: Ex vivo culture of intact human patient derived pancreatic tumour tissue

This paper develops an ex vivo explant model of human pancreatic tumour tissue that maintains 3D architecture and microenvironmental cues, enabling study of PDAC biology and therapeutic response.

Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells

The paper compares functional differences between two culture methods for nasal epithelial cells and finds significant variations in barrier integrity and CFTR-mediated chloride currents despite similar morphology and proteomics.

Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model

This study shows that γ-glutamylcysteine (GGC) reduces LPS-induced oxidative stress and improves cell viability in a cystic fibrosis model.

Disruption of membrane cholesterol organization impairs the concerted activity of PIEZO1 channel clusters

This study shows that membrane cholesterol organization is critical for PIEZO1 channel cluster function, affecting their response to mechanical force and synchronization.

Modular actin nano-architecture enables podosome protrusion and mechanosensing

This study identifies the modular actin nano-architecture of podosomes, showing how different actin modules enable protrusion and mechanosensing on varying substrate stiffness.

Translocator Protein Localises To CD11b+ Macrophages In Atherosclerosis

This study shows TSPO ligand 18F-PBR111 accumulates in atherosclerotic plaques and identifies CD11b+ macrophages as key TSPO-expressing cells during lesion progression.

Conformational states control Lck switching between free and confined diffusion modes in T cells

This study shows that Lck's conformational states determine its diffusive behavior in T cells, with open conformations leading to confined diffusion and closed conformations allowing free diffusion.