Author

R. Whan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1

Frequent Co-Authors

E. Pandzic· 3 shared B. J. Cochran· 2 shared K.-A. Rye· 2 shared S. Waters· 2 shared A. Arthur· 1 shared A. Capraro· 1 shared A. Dupuy· 1 shared A. Jaffe· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

E. Pandzic

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ApoA-I Protects Pancreatic β-cells from Cholesterol-induced Mitochondrial Damage and Restores their Ability to Secrete Insulin

B. Manandhar, E. Pandzic, N. Deshpande, S.-Y. Chen, V. Wasinger, M. Kockx, E. N. Glaros, K. L. Ong, S. R. Thomas, M. Wilkins, R. Whan, B. J. Cochran, K.-A. Rye

This study shows apoA-I improves β-cell insulin secretion by reducing oxidative stress and enhancing mitochondrial function in cholesterol-loaded cells.

bioRxiv · Apr 3, 2023Cell Biology

Precision super-resolution cryo-correlative light and electron microscopy for rapid in situ structural analyses of optogenetically-positioned organelles

G. M. I. Redpath, J. A. Rae, Y. Yao, J. Ruan, M. L. Cagigas, R. Whan, E. C. Hardeman, P. W. Gunning, V. Ananthanarayanan, R. G. Parton, N. Ariotti

The paper develops a cryo-CLEM workflow using optogenetics to enable rapid in situ structural analysis of organelles without cryo-focused ion beam milling.

bioRxiv · Nov 22, 2022Cell Biology

Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

E. M. Poursani, D. Mercatelli, P. Raninga, J. L. Bell, F. Saletta, F. V. Kohane, Y. Zheng, J. Rouaen, T. R. Jue, F. T. Michniewicz, E. Kasiou, M. Tsoli, G. Cirillo, S. Waters, T. Shai-Hee, , O. VITTORIO

This paper shows copper chelation inhibits TGF-β pathways and reduces EMT in cancer cells, potentially offering a new therapeutic strategy for targeting TGF-β in cancer.

bioRxiv · Oct 3, 2022 · PreprintCancer Biology

Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells

N. T. Awatade, S. L. Wong, E. Pandzic, I. Slapetova, A. Capraro, L. Zhong, N. Turgutoglu, L. K. Fawcett, R. Whan, A. Jaffe, S. Waters

The paper compares functional differences between two culture methods for nasal epithelial cells and finds significant variations in barrier integrity and CFTR-mediated chloride currents despite similar morphology and proteomics.

bioRxiv · May 29, 2020Physiology

Translocator Protein Localises To CD11b+ Macrophages In Atherosclerosis

C. Kopecky, E. Pandzic, A. Parmar, J. Szajer, V. Lee, A. Dupuy, A. Arthur, S. Fok, R. Whan, W. J. Ryder, K.-A. Rye, B. J. Cochran

This study shows TSPO ligand 18F-PBR111 accumulates in atherosclerotic plaques and identifies CD11b+ macrophages as key TSPO-expressing cells during lesion progression.

bioRxiv · Dec 15, 2018Pathology