S. L. Wong

Uncovering strain- and age-dependent differences in innate immune response to SARS-CoV-2 infection in nasal epithelia using 10X single-cell sequencing

The paper uses single-cell sequencing to compare innate immune responses to SARS-CoV-2 in nasal epithelial cells from adults and adolescents, finding age- and strain-dependent differences.

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors

This study evaluates six AAV vectors in twelve preclinical liver models to identify the most predictive for AAV capsid selection in human hepatocyte transgene delivery.

Enterococcus faecalis and Staphylococcus aureus mixed species infection attenuates pathogen-specific neutrophil responses and impairs bacterial clearance

This study shows that E. faecalis and S. aureus co-infection reduces neutrophil responses, enhancing survival of both pathogens through immune suppression.

Ageing impairs the airway epithelium defence response to SARS-CoV-2

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells

The paper compares functional differences between two culture methods for nasal epithelial cells and finds significant variations in barrier integrity and CFTR-mediated chloride currents despite similar morphology and proteomics.

Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model

This study shows that γ-glutamylcysteine (GGC) reduces LPS-induced oxidative stress and improves cell viability in a cystic fibrosis model.

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin de-condensation and nuclear envelope rupture

This study uses live-cell imaging to characterize the step-wise cellular events of NETosis in neutrophils and identifies PAD4's role in chromatin de-condensation and nuclear envelope rupture.