Author

I. T.-L. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:clustering· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

J. Luebeck· 3 shared P. S. Mischel· 3 shared V. Bafna· 3 shared J. T. Lange· 2 shared S. R. Dehkordi· 2 shared A. Caplin· 1 shared A. G. Henssen· 1 shared A. Tiwari· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

J. Luebeck

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 12, 2023

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

S. R. Dehkordi, I. T.-L. Wong, J. Ni…·V. Bafna

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

DOI 10.1101/2023.12.12.571349

humanwhole-genome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 18, 2023

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

K. L. Hung, M. G. Jones, I. T.-L. Wong…·H. Y. Chang

This study shows that multiple extrachromosomal DNA species are coordinately inherited in cancer cells through mitotic co-segregation, enabling oncogene cooperation and guiding therapeutic strategies.

DOI 10.1101/2023.07.18.549597

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 18, 2021

The landscape of extrachromosomal circular DNA in medulloblastoma

O. S. Chapman, J. Luebeck, S. Wani…·L. Chavez

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

DOI 10.1101/2021.10.18.464907

humanwhole-genome sequencing

𝕏 PostBluesky