Author

J. T. Lange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:clustering· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. S. Mischel· 4 shared V. Bafna· 4 shared H. Y. Chang· 3 shared K. L. Hung· 3 shared A. G. Henssen· 2 shared B. Werner· 2 shared I. T.-L. Wong· 2 shared J. Luebeck· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

P. S. Mischel

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Author profile →

4 papers

Recent·Most cited

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

K. L. Hung, M. G. Jones, I. T.-L. Wong, J. T. Lange, J. Luebeck, E. Scanu, B. J. He, L. Brückner, R. Li, R. C. Gonzalez, R. Schmargon, J. R. Dörr, J. A. Belk, V. Bafna, B. Werner, , H. Y. Chang

This study shows that multiple extrachromosomal DNA species are coordinately inherited in cancer cells through mitotic co-segregation, enabling oncogene cooperation and guiding therapeutic strategies.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

The landscape of extrachromosomal circular DNA in medulloblastoma

O. S. Chapman, J. Luebeck, S. Wani, A. Tiwari, M. Pagadala, S. Wang, J. D. Larson, J. T. Lange, I. T.-L. Wong, S. R. Dehkordi, S. Chandran, M. Adam, Y. Lin, E. Juarez, J. T. Robinson, , L. Chavez

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers

J. T. Lange, C. Y. Chen, Y. Pichugin, F. Xie, J. Tang, K. L. Hung, K. E. Yost, Q. Shi, M. L. Erb, U. Rajkumar, S. Wu, C. Swanton, Z. Liu, W. Huang, H. Y. Chang, , P. S. Mischel

bioRxiv · Jun 11, 2021 · PreprintCancer Biology

EcDNA hubs drive cooperative intermolecular oncogene expression

K. L. Hung, K. E. Yost, L. Xie, S. Wu, J. T. Lange, C. V. Duffy, K. Kraft, J. Tang, Q. Shi, J. C. Rose, M. R. Corces, J. M. Granja, R. Li, U. Rajkumar, R. Tjian, , H. Y. Chang

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

bioRxiv · Nov 19, 2020Cancer Biology