Author

I. Tikhonova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. A. Guseinov· 2 shared A. Kissenpfennig· 1 shared A. R. B. Thomsen· 1 shared A. Short· 1 shared A. Wright· 1 shared A. Yakkundi· 1 shared B. Plouffe· 1 shared C. Campbell· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. A. Guseinov

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for the ligand recognition and signaling of free fatty acid receptors

X. Zhang, A. A. Guseinov, L. Jenkins, K. Li, I. Tikhonova, G. Milligan, C. Zhang

The paper determines the structures of FFA1 and FFA4 bound to fatty acids and elucidates their activation mechanisms through cryo-EM and computational methods.

bioRxiv · Aug 20, 2023Pharmacology & Toxicology

β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

C. Daly, A. A. Guseinov, H. Hahn, A. Wright, I. Tikhonova, A. R. B. Thomsen, B. Plouffe

This study shows the vasopressin type 2 receptor can activate G proteins at endosomes both with and without beta-arrestin, challenging existing models of GPCR signaling.

bioRxiv · Apr 1, 2023Cell Biology

The immunophilin protein FKBPL and its peptide derivatives are novel regulators of vascular integrity and inflammation via NF-kappaB signaling

S. L. Annett, S. Spence, C. Garciarena, C. Campbell, M. Dennehy, C. Drakeford, J. Lai, J. Dowling, G. Moore, A. Yakkundi, A. Short, D. Sharpe, F. Furlong, J. O'Donnell, G. Cavalleri, , T. Robson

This paper identifies FKBPL and its peptides as regulators of vascular integrity and inflammation via NF-kappaB signaling, showing therapeutic potential in inflammatory diseases.

bioRxiv · Feb 24, 2021 · PreprintImmunology