L. Jenkins

Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity

This study shows that bacterial differentiation through altruistic feeding and cell-cell signaling increases phenotypic heterogeneity, enhancing population resilience to environmental changes.

Phosphorylation bar-coding of Free Fatty Acid receptor 2 is generated in a tissue-specific manner

The paper demonstrates tissue-specific phosphorylation patterns of FFA2 in response to the same agonist in different tissues using transgenic mice and phospho-specific antibodies.

Structural basis for the ligand recognition and signaling of free fatty acid receptors

The paper determines the structures of FFA1 and FFA4 bound to fatty acids and elucidates their activation mechanisms through cryo-EM and computational methods.

Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease

This study shows that phosphorylation and arrestin-dependent signaling of the M1 muscarinic receptor provides neuroprotection in prion disease, suggesting potential for developing safer therapies for neurodegenerative diseases.

EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis

This study shows that EHF is essential for epidermal and colonic epithelial homeostasis and acts as a tumor suppressor in colorectal cancer.

Stromal Oncostatin M axis promotes breast cancer progression

This study identifies the stromal OSM:OSMR axis as a key driver of breast cancer progression by reprogramming the tumor microenvironment.

Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

The paper identifies a specific cancer-associated fibroblast subset that supports tumour growth and metastasis by expressing Endo180, and shows that targeting this subset can limit tumour progression.

Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis

This study identifies a specific agonist for a modified FFA2 receptor and demonstrates distinct roles of FFA2 and FFA3 in gut-brain communication using genetically engineered mice.

Gene fitness landscape of group A streptococcus during necrotizing myositis

This study identifies GAS genes critical for necrotizing myositis in nonhuman primates using TraDIS, highlighting transporter genes as key contributors to pathogenesis.