Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing
A. Pouikli, S. Parekh, M. Maleszewska, M. Baghdadi, I. Tripodi, C. Nikopoulou, K. Folz-Donahue, Y. Hinze, A. Mesaros, P. Giavalisco, R. Dowell, L. Partridge, P. Tessarz
This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.
bioRxiv · Apr 2, 2020 · PreprintCell Biology