P. Giavalisco

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression

This study shows NME6 supplies mitochondria with ribonucleotides to support mitochondrial gene transcription and DNA maintenance, with implications for cancer and autoimmune diseases.

Single-cell resolution unravels spatial alterations in metabolism, transcriptome and epigenome of ageing liver

The paper investigates age-related spatial changes in metabolism, transcriptome, and epigenome in the murine liver using multi-omics approaches.

CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

This study shows CLUH regulates astrin-1 expression to link mitochondrial metabolism with cell cycle progression.

P2Y6 receptor signaling in natural killer cells impairs insulin sensitivity in obesity

This study shows that blocking P2Y6R in NK cells improves insulin sensitivity in obese mice by reducing adipose tissue inflammation and glucose production.

Reduced purine biosynthesis in humans after their divergence from Neandertals

The paper compares metabolomes across humans, chimpanzees, and macaques to identify reduced purine biosynthesis in humans, linked to an amino acid substitution in adenylosuccinate lyase.

Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics

This study identifies spermidine, MK-2206, and niclosamide as potential antiviral therapeutics by enhancing autophagy against SARS-CoV-2 in vitro.

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing

This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.

Mitochondria-ER contacts in reactive astrocytes coordinate local perivascular domains to promote vascular remodelling

This study shows that mitochondrial dynamics in astrocytes coordinate perivascular domains to promote vascular remodeling after injury.