M. Maleszewska

This study shows that high oxygen levels impair osteogenesis in MSCs by disrupting mito-nuclear communication through chromatin compaction and histone hypo-acetylation, which can be reversed by acetate supplementation.

The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.

This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.