Author

C. Nikopoulou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 4

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Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:metabolomics· 2 Approach:statistical model· 2

Frequent Co-Authors

P. Tessarz· 4 shared S. Parekh· 4 shared A. Pouikli· 2 shared F. Schneider· 2 shared M. Maleszewska· 2 shared P. Giavalisco· 2 shared T. Sandoval· 2 shared V. Kondylis· 2 shared

Activity by Year

2020-2022 · peak 2/yr

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10 top collaborators · 36 mutual co-author links

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4 shared papersCell Biology

P. Tessarz

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4 papers

Recent·Most cited

Hypoxia promotes osteogenesis via regulation of the mito-nuclear communication

A. Pouikli, M. Maleszewska, S. Parekh, C. Nikopoulou, J.-J. Bonfiglio, C. Mylonas, T. Sandoval, A.-L. Schumacher, Y. Hinze, I. Matic, P. Tessarz

This study shows that high oxygen levels impair osteogenesis in MSCs by disrupting mito-nuclear communication through chromatin compaction and histone hypo-acetylation, which can be reversed by acetate supplementation.

bioRxiv · Feb 26, 2022 · PreprintCell Biology

Single-cell resolution unravels spatial alterations in metabolism, transcriptome and epigenome of ageing liver

C. Nikopoulou, N. Kleinenkuhnen, S. Parekh, T. Sandoval, F. Schneider, P. Giavalisco, M. Bozukova, A. J. Vesting, J. Altmueller, T. Wunderlich, V. Kondylis, A. Tresch, P. Tessarz

The paper investigates age-related spatial changes in metabolism, transcriptome, and epigenome in the murine liver using multi-omics approaches.

bioRxiv · Dec 14, 2021 · PreprintCell Biology

Single organoid RNA-sequencing reveals high organoid-to-organoid variability

K. Gehling, S. Parekh, F. Schneider, M. Kirchner, V. Kondylis, C. Nikopoulou, P. Tessarz

This study uses RNA-seq to show that organoids vary significantly between individuals within a culture, but not between batches, suggesting microenvironmental effects drive this variability.

bioRxiv · Nov 22, 2021 · PreprintCell Biology

Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing

A. Pouikli, S. Parekh, M. Maleszewska, M. Baghdadi, I. Tripodi, C. Nikopoulou, K. Folz-Donahue, Y. Hinze, A. Mesaros, P. Giavalisco, R. Dowell, L. Partridge, P. Tessarz

This study shows that ageing reduces osteogenic potential of mesenchymal stem cells due to deregulated mito-nuclear communication, which leads to hypo-acetylation and chromatin compaction, and that acetate supplementation can reverse these effects.

bioRxiv · Apr 2, 2020 · PreprintCell Biology