An adaptive compromise - Conflicting evolutionary pressures on arthropod borne Zika virus dinucleotide composition in mammalian hosts and mosquito vectors
J. J. Fros, I. Visser, B. Tang, K. Yan, E. Nakayama, T. M. Visser, C. J. M. Koenraadt, M. M. van Oers, G. P. Pijlman, A. Suhrbier, P. Simmonds
This study investigates how Zika virus balances CpG suppression in vertebrate hosts with different compositional needs in mosquito vectors, showing that CpG-high mutants replicate better in mosquitoes and show vaccine potential in mice.
bioRxiv · Feb 9, 2021Microbiology