K. Yan

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

TMEM106B-mediated SARS-CoV-2 infection allows for robust ACE2-independent infection in vitro but not in vivo

This study identifies TMEM106B as a key mediator of ACE2-independent SARS-CoV-2 infection in vitro but shows no in vivo neuroinvasiveness or respiratory tract replication in mice.

Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice

This study tracks inflammation resolution in lungs of K18-hACE2 mice infected with SARS-CoV-2 omicron BA.1, showing reduced cytokine signatures and increased anti-inflammatory cell types over time.

Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

This study shows that microplastics co-delivered with SARS-CoV-2 in mice suppress early innate immune responses but promote a cytokine release syndrome signature later in infection.

Structural insights into abscisic acid exporter AtABCG25

The paper determines the structure of AtABCG25, an ABA exporter, revealing its mechanism of ABA binding and transport through cryo-EM.

Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoids

This study compares the neurovirulence of JEV genotype 4 (JEVNSW/22) with genotypes 2 and 3 in mice and human brain organoids, finding JEVNSW/22 less neurovirulent and more sensitive to type I interferon.

Increased neurovirulence of omicron BA.5 and XBB variants over BA.1 in K18-hACE2 mice and human brain organoids

This study shows that omicron BA.5 and XBB variants are more neurovirulent than BA.1 in mice and human brain organoids, leading to increased brain infection and mortality.

ACE2-independent SARS-CoV-2 infection and mouse adaption emerge after passage in cells expressing human and mouse ACE2

The paper describes the generation of mouse-adapted SARS-CoV-2 variants through serial passaging in co-cultures of human and mouse ACE2-expressing cells, revealing ACE2-independent infection capabilities.

Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

The paper demonstrates that a simple system of dynein, microtubules, and DNA origami crosslinkers can produce oscillatory movement and repetitive bending without additional regulatory structures.

Regulation of drought tolerance in Arabidopsis involves PLATZ4-mediated transcriptional suppression of PIP2;8

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis

This study shows that microplastic consumption in mice causes mild colon inflammation and prolongs viral arthritis by increasing Th1, NK cell, and neutrophil signatures.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

This study identifies how ZIKV sfRNA interacts with NS5 to inhibit STAT1 phosphorylation, promoting viral pathogenesis in placental and neural tissues.

An inconvenient association between granzyme A and Nicotinamide Nucleotide Transhydrogenase

The paper identifies an association between granzyme A and Nicotinamide Nucleotide Transhydrogenase in mice, showing that Nnt, not GzmA loss, affects disease outcomes and highlights inconsistencies in Nnt sequencing data.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions

This paper develops an ACE2-lentivirus system to enable SARS-CoV-2 infection in mice, showing it can model viral replication, inflammation, and vaccine testing.

An adaptive compromise - Conflicting evolutionary pressures on arthropod borne Zika virus dinucleotide composition in mammalian hosts and mosquito vectors

This study investigates how Zika virus balances CpG suppression in vertebrate hosts with different compositional needs in mosquito vectors, showing that CpG-high mutants replicate better in mosquitoes and show vaccine potential in mice.

SiCEP3, a C-terminally encoded peptides from Setaria italica, promotes ABA import and signaling pathway

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

Simple rapid in vitro screening method for SARS-CoV-2 anti-virals that identifies potential cytomorbidity-associated false positives

A Holistic Analysis of the Intestinal Stem Cell Niche Network

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

Leukocyte-derived High-mobility group box 1 controls innate immune responses against Listeria monocytogenes.

This study shows that HMGB1 from leukocytes is critical for immune responses against Listeria monocytogenes, while hepatocyte HMGB1 is not essential for moderate infections but may contribute to excessive inflammation in severe cases.

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

This study uses 3D colorectal cancer organoids to assess responses to Tankyrase inhibitors, showing morphometric analysis can detect drug effects on cancer stem cells.