Author

I. Zaretsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

S. J. Fleishman· 2 shared A. Noronha· 1 shared A. Tennenhouse· 1 shared D. Fass· 1 shared E. Makowski· 1 shared J. Abramson· 1 shared L. Khmelnitsky· 1 shared M. Goldsmith· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

S. J. Fleishman

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Author profile →

2 papers

Recent·Most cited

Stable mammalian serum albumins designed for bacterial expression

O. Khersonsky, M. Goldsmith, I. Zaretsky, S. Hamer-Rogotner, O. Dym, T. Unger, M. Yona, Y. Fridmann-Sirkis, S. J. Fleishman

This paper designs stable mammalian serum albumins for bacterial expression, showing improved thermostability and ligand binding properties.

bioRxiv · Mar 28, 2023Biochemistry

Reliable energy-based antibody humanization and stabilization

A. Tennenhouse, L. Khmelnitsky, R. Khalaila, N. Yeshaya, A. Noronha, M. Lindzen, E. Makowski, I. Zaretsky, Y. Fridmann Sirkis, Y. Galon-Wolfenson, P. M. Tessier, J. Abramson, Y. Yarden, D. Fass, S. J. Fleishman

The paper introduces CUMAb, a computational method for humanizing antibodies that improves stability and binding by systematically grafting CDRs onto human frameworks and ranking designs using Rosetta simulations.

bioRxiv · Aug 14, 2022Bioengineering